Study of the correlation between vitamin D level and liver function in children with infectious mononucleosis

Objective To investigate the correlation between the serum level of 25-hydroxyvitamin D （25（OH）D） and liver function in children with infectious mononucleosis （IM）. Methods Ninety children with acute IM were enrolled into the IM group， and 40 healthy children who underwent physical examination during the same period were allocated into the control group. Serum level of 25（OH）D was determined by electrochemiluminescence and the viral load of Epstein-Barr virus DNA （EBV-DNA） in plasma was determined by quantitative fluorescent RT-PCR. Clinical data and serum 25（OH） D levels were compared between two groups. The correlation between 25（OH）D level and atypical lymphocytes， liver function parameters and plasma EBV-DNA in children with IM was analyzed. Results Serum 25（OH）D level in the IM group was significantly lower， whereas the 25（OH）D inadequacy rate was significantly higher than those in the control group （both P < 0.05）. Serum 25（OH）D level was negatively correlated with atypical lymphocytes in the IM group （P < 0.05）. The levels of alanine aminotransferase （ALT）， aspartate aminotransferase （AST）， glutamyl transpeptidase （GGT）， and adenosine deaminase （ADA） in IM children with serum 25（OH）D inadequacy were higher than those in their counterparts with adequate serum 25（OH）D （all P < 0.05）. No significant differences were found in total bilirubin （TBIL）， direct bilirubin （DBIL） and plasma EBV-DNA load between the adequate and inadequate subgroups （all P > 0.05）. In the IM group， serum 25（OH）D level was negatively correlated with ALT， GGT， and ADA （all P < 0.05）， whereas positively correlated with CHE （P < 0.05） and had no correlation with AST， TBIL or DBIL （all P > 0.05）. Conclusions Serum vitamin D insufficiency occurs in children with IM. Vitamin D may be involved in the incidence and development of the course of IM， which is probably associated with liver function impairment

Research on Green Building Design Optimization Based on Building Information Modeling and Improved Genetic Algorithm

The energy consumption of the construction industry has been increasing year by year, posing a huge challenge to China’s dual carbon goals of peaking carbon emissions and achieving carbon neutrality. The Chinese construction industry has huge potential for energy conservation and emission reduction, and the government has therefore put forward requirements for constructing green buildings and formulated strict evaluation standards. The carbon emissions of the construction industry involve various stages of the entire life cycle and are closely related to the green building design standards that meet the requirements. This article sets multiple objective functions based on the two dimensions of the carbon emissions of the entire life cycle of buildings and green building evaluation and uses the NSGA-II algorithm in genetic algorithms to optimize ten indicators selected from the two objectives. Based on this, building information modeling (BIM) modeling was carried out for an office building project in Southwest China, and energy consumption analysis and evaluation were conducted based on the project’s multidisciplinary model. The dialectical relationship between the carbon emissions of the entire life cycle of buildings and the green building evaluation values was discovered, and the optimized parameter combination scheme corresponding to the Pareto solution set was obtained, providing a reference for using improved genetic algorithms and BIM technology to optimize green building design

Petrogenesis of granitic pegmatite veins: Perspectives from major element and B isotope in tourmalines, Chakabeishan, Northern Tibetan Plateau

The petrogenesis of regionally zoned granitic pegmatite veins remains debated. Because of the economic significance, we carried out a study on the Chakabeishan (CKBS) pegmatite-type Li-Be deposit, eastern North Qaidam Tectonic Belt, Northern Tibetan Plateau, by means of in-situ major element and B isotope compositions of tourmalines in the beryl-bearing and spodumene-bearing pegmatite veins. Tourmalines (Tur-Be) from the beryl-bearing pegmatite are homogeneous schorl with low Mg/(Mg + Fe), high Na/(Na + Ca) and YAl, suggesting that they are of magmatic origin. Two generations of tourmalines (Tur-Li) from the spodumene-bearing pegmatite are identified: (i) the crystal cores (mostly elbaite and Li-rich schorl with subordinate schorl) are consistent with being of magmatic origin crystallized at the magmatic stage; (ii) the crystal rims (schorl) are best understood as the overgrowth at the later hydrothermal stage. Tur-Be and Tur-Li show an obvious difference in core-to-rim B isotopic variation trend with δ11B decrease in Tur-Be and increase in Tur-Li. The core-to-rim δ11B decrease in Tur-Be results from degassing during its host pegmatitic melt evolution, whereas the core-to-rim δ11B increase in Tur-Li is related to fluid exsolution. The estimated δ11B values for the initial melts of the beryl-bearing and spodumene-bearing pegmatites are −10.46‰ and −10.78‰, respectively, indicating that they most likely originate from protracted fractional crystallization/differentiation of granitic intrusions rather than partial melting of metapelite. Both Mg/(Mg + Fe) ratios and Li abundances in the cores of Tur-Be are lower than those of Tur-Li, suggesting that Tur-Li crystallizes from chemically more evolved melts

Age and Composition of Columbite-Tantalite Group Minerals in the Spodumene Pegmatite from the Chakabeishan Deposit, Northern Tibetan Plateau and Their Implications

The Chakabeishan (CKBS) deposit is the first pegmatite-type Li-Be deposit discovered in the eastern North Qaidam Tectonic Belt (NQTB) of Tibetan Plateau. The correct understanding of its petrogenesis and the precise determination of its formation age are of great significance for further regional prospecting and the discovery of new economically valuable rare-metal deposits. Therefore, a systematic study of texture, major-element composition, and U-Pb dating of columbite-tantalite group minerals (CGMs) in the spodumene pegmatite dyke from the CKBS deposit was undertaken. Three types of CGMs were identified, including concentric oscillatory ferrocolumbite (CGMs-1), homogeneous ferrocolumbite (CGMs-2), and irregular ferrotantalite (minor manganocolumbite) with abundant early ferrocolumbite replacement remnants (CGMs-3). The zoning patterns and chemical compositions in the CGMs record the complex evolutionary history of their host pegmatite from the magmatic stage (CGMs-1, disequilibrium crystallization) to the magmatic-hydrothermal transition stage (CGMs-2, equilibrium crystallization) and then to the late metasomatic stage (CGMs-3, replacement/re-equilibrium). CGMs U-Pb dating results suggest that the spodumene pegmatite dyke (No.15) emplaced at 230.1 ± 2.6 Ma. Subsequently, it experienced fluid metasomatism at 221 ± 5.3 Ma. Based on the new age data and published geochronological data, it can be concluded that the spodumene pegmatite dykes in the CKBS deposit formed in an oceanic subduction-related setting, representing a new metallogenic event in western China. Except for the CKBS deposit, a large number of rare-metal pegmatite dykes have also been discovered in the eastern NQTB, indicating that the eastern NQTB may be an important potential rare-metal metallogenic belt that should be explored in detail and arouse painstaking attention